E. P. Yalcintas1, J. Hu1, Y. Liu1,2, A. Voloshin1,2,3
CMES-Computer Modeling in Engineering & Sciences, Vol.98, No.2, pp. 151-180, 2014, DOI:10.3970/cmes.2014.098.151
Abstract Mechanical behavior of cells plays a crucial role in response to external stimuli and environment. It is very important to elucidate the mechanisms of cellular activities like spreading and alignment as it would shed light on further biological concepts. In this study, a multi-scale computational approach is adopted by modeling the cytoskeleton of cell as a tensegrity structure. The model is based on the complementary force balance between the tension and compression elements, resembling the internal structure of cell cytoskeleton composed of microtubules and actin filaments. The effect of surface topology on strain energy of a spread cell is investigated… More >
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