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    ABSTRACT

    DNA Cracks at the Region of Protein Binding Under the Action of Stretch

    Qingjia Chi*, Xinge Geng

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.22, No.1, pp. 118-118, 2019, DOI:10.32604/icces.2019.05168

    Abstract The binding of DNA to protein in the cellular nucleus is a common phenomenon. DNA molecules will soften at the binding region when they adhere to proteins. Softening will affect the mechanical properties significantly. However, the mechanism underlying the mechanical softening remains to be explored. To understand the changes in the mechanical properties of DNA, the peridynamics technique can effectively capture the stress of the softened DNA under tensile forces. And later the results were verified by finite element computations. Utilizing the computations of perydynamics to reveal the stretch of the double-stranded DNA. The results demonstrated DNA was easy to… More >

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