JIUCHUN GUO1, JIE PAN2,*, QIANQIAN GUO2
BIOCELL, Vol.46, No.2, pp. 505-510, 2022, DOI:10.32604/biocell.2021.015785
Abstract The excessive energy of light, especially the invisible rays with lower wavelength, is basically absorbed by retinal
pigment epithelium (RPE) and usually causes DNA damage. The molecular mechanism behind DNA damage repair
response to this frequent stress in RPE is not clearly understood. In this study, we determined that the Fanconi
anemia (FA) pathway was activated in human RPE ARPE-19 cells after ultraviolet (UV) B and C treatment.
Moreover, immunoprecipitation (IP) of FANCD2 indicated that denticleless E3 ubiquitin protein ligase homolog
(DTL) closely interacted with FANCD2. Knockdown of DTL weakened the activity of the FA pathway in ARPE-19
cells responding… More >
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