Zahra HOSSEININIA1, Sara SOLTANIAN2, Naser MAHDAVI-SHAHRI3, Hesam DEHGHANI1,4
BIOCELL, Vol.43, No.3, pp. 145-154, 2019, DOI:10.32604/biocell.2019.06468
Abstract Maintenance of pluripotency depends to diverse regulatory factors. Studies in embryonic stem cells
(ESCs) have indicated that large intergenic non-coding RNAs (lincRNAs) are involved in the regulatory network
of pluripotency. However, the presence and function of pluripotency-associated lincRNAs in cancer cells with
pluripotency features are unknown. In this study, we used embryonal carcinoma (EC) P19 cell lines to investigate the
expression level of Halr1 in pluripotency and retinoic acid (RA)-induced differentiated states. Down-regulation of
pluripotency associated factors such as OCT4, NANOG, SSEA1 and alkaline phosphatase at transcript and protein
levels were used to confirm the differentiated status of P19 cells.… More >
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