CONGCHEN BAI1, QIHANG KONG2, HAO TANG2, SHUWEN ZHANG2, JUNTENG ZHOU3,*, XIAOJING LIU2,4,*
BIOCELL, Vol.47, No.11, pp. 2517-2533, 2023, DOI:10.32604/biocell.2023.043864
Abstract Background: Various physiological mechanisms are linked to dilated cardiomyopathy (DCM) development,
including oxidative stress, immune irregularities, inflammation, fibrosis, and genetic changes. However, precise
molecular drivers of DCM, especially regarding abnormal immune responses, remain unclear. This study investigates
immune-related long non-coding RNAs (lncRNAs) in DCM’s diagnostic and therapeutic potential. Methods:
GSE141910, GSE135055, and GSE165303 datasets were acquired from the GEO database. LASSO, SVM-RFE, and
random forest algorithms identified DCM-associated immune-related lncRNAs. Diagnostic capabilities were assessed
by Nomogram and receiver operating characteristic (ROC) curves. Multivariate linear regression explored lncRNA
correlations with ejection fraction. Single-sample gene set enrichment analysis (ssGSEA) gauged immune cell… More >
Graphic Abstract
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