YUE WANG1,#, YINPING DUAN1,#, KUNLIN CHEN3, HUIXIA LI1,2,*, YAN QUAN4,*
BIOCELL, Vol.45, No.2, pp. 307-316, 2021, DOI:10.32604/biocell.2021.014305
Abstract Non-alcoholic fatty liver disease is the most common cause of hepatic dysfunction. In the present study, human
normal hepatocyte L02 cells were treated with 50% fetal bovine serum to induce the formation of hepatic steatosis in vitro,
and then the cells were treated with docosahexaenoic acid to investigate its protective effect on Non-alcoholic fatty liver
disease. Our results showed that 50% of fetal bovine serum significantly induced intracellular lipid accumulation and
hepatocyte fatty degeneration within 48 h. The expression level of adipose formation-related genes was significantly
up-regulated, such as PPARγ, C/EBPα and SREBP-1; meanwhile, the content of cellular total lipid,… More >
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