Xiaojuan He¹, Chanyuan Li¹, Shaokang Wang¹, Jingyi Zhu¹, Yabin Zhang^1,*, Zhen Guo², Lihua Wu^3,*

Journal of Polymer Materials, Vol.41, No.4, pp. 263-279, 2024, DOI:10.32604/jpm.2024.055821 - 16 December 2024

Abstract Eye drops are the usual method to treat eye diseases, and gel polymer provides the carrier which could be used for ophthalmic drug delivery. However, the stable and sustained release is the main issue for the ophthalmic drug and is concerned by many researchers. In this study, composite hydrogels were prepared using 2-hydroxyethyl methacrylate (HEMA), and N-vinyl-2-pyrrolidone (NVP) used for ophthalmic drug loading and release. According to the results of Fourier transform infrared spectroscopy (FTIR), the disappearance of the C=C bond in hydrogel indicated that the copolymerization reaction between HEMA and NVP was successful. The… More > Graphic Abstract

FRANCESCO PETRELLA^*, ENRICO MARIO CASSINA, LIDIA LIBRETTI, EMANUELE PIRONDINI, FEDERICO RAVEGLIA, ANTONIO TUORO

Oncology Research, Vol.32, No.3, pp. 433-437, 2024, DOI:10.32604/or.2023.046497 - 06 February 2024

Abstract The main aim of antineoplastic treatment is to maximize patient benefit by augmenting the drug accumulation within affected organs and tissues, thus incrementing drug effects and, at the same time, reducing the damage of non-involved tissues to cytotoxic agents. Mesenchymal stromal cells (MSC) represent a group of undifferentiated multipotent cells presenting wide self-renewal features and the capacity to differentiate into an assortment of mesenchymal family cells. During the last year, they have been proposed as natural carriers for the selective release of antitumor drugs to malignant cells, thus optimizing cytotoxic action on cancer cells, while More >

Xiaoliang Zhao^1,#, Yuting Wang^1,#, Xiuying Pu¹, Jianzhong Ma¹, Feifan Leng¹, Yonggang Wang¹, Yanling Wang¹, Shuhong Yang¹, Fen Ran², Weijie Zhang^1,*

Journal of Renewable Materials, Vol.7, No.12, pp. 1321-1332, 2019, DOI:10.32604/jrm.2019.07757

Abstract A series of the Guiqi polysaccharides/chitosan/alginate composite hydrogel microspheres (GPcM) with different particle sizes were prepared with Guiqi polysaccharides (GP), chitosan (CS) and sodium alginate (Alg). The optimum preparation process was also determined by single factor and orthogonal experiment analysis. The GPcM were characterized by fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), drug loading efficiency test (LE), encapsulation efficiency test (EE) and in vitro release study. The results showed that the Guiqi polysaccharides chitosan hydrogel (GPCH) and sodium alginate hydrogel (SAH) formed a crossover system in GPcM. The GPcM have a uniform particle More >