MASASHI KAWAMI*, RYOKO YUMOTO, MIKIHISA TAKANO
BIOCELL, Vol.46, No.8, pp. 1861-1865, 2022, DOI:10.32604/biocell.2022.019667
Abstract A number of drugs induce pulmonary injury and subsequently lead to serious lung diseases such as pulmonary
fibrosis as the adverse drug reactions. However, an effective preventive approach against drug-induced pulmonary fibrosis
has not been established due to poor understanding of common preventive targets in a variety of drugs showing pulmonary
toxicity. Epithelial-mesenchymal transition (EMT), a cellular phenotypic change of the epithelial to mesenchymal state,
contributes to the development of pulmonary fibrosis through the conversion of damaged alveolar epithelium into
myofibroblasts. As several drugs with pulmonary toxicity have been reported to induce EMT, EMT serves as a bridge
between the… More >
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