PIAO YANG¹, MOHSEN SHEYKHHASAN^2,*, REZA HEIDARI³, MOHSEN CHAMANARA^4,5, PAOLA DAMA⁶, AMIRHOSSEIN AHMADIEH-YAZDI⁷, HAMED MANOOCHEHRI⁸, HAMID TANZADEHPANAH⁹, HANIE MAHAKI¹⁰, NASER KALHOR¹¹, ASHKAN DIRBAZIYAN¹², SHARAFALDIN AL-MUSAWI¹³

Oncology Research, Vol.33, No.2, pp. 283-300, 2025, DOI:10.32604/or.2024.052939 - 16 January 2025

Abstract Cancer, a leading cause of global mortality, remains a significant challenge to increasing life expectancy worldwide. Forkhead Box R2 (FOXR2), identified as an oncogene within the FOX gene family, plays a crucial role in developing various endoderm-derived organs. Recent studies have elucidated FOXR2-related pathways and their involvement in both tumor and non-tumor diseases. Dysregulation of FOXR2 has been linked to numerous malignant tumors, spanning the brain, nervous system, thyroid, osteosarcoma, Hodgkin lymphoma, colorectal, liver, pancreatic, lung, breast, ovarian, prostate, female genital tract, endometrial, and uterine cancers. Despite extensive research on FOXR2 dysregulation, its practical applications More >

MAHMOUD M. ABDELFATTAH¹, REHAM HELWA^1,2,*

Oncology Research, Vol.30, No.3, pp. 129-135, 2022, DOI:10.32604/or.2022.026838 - 12 January 2023

Abstract Galectins are sticky molecules that bind to β-galactoside. Their interactions render them essential players in many cellular processes. The imbalance of galectin expression was reported in many diseases. In cancer, galectins interact with the extracellular matrix, evade the immune system, and potentially have broad interactions with blood components. In the last ten years, since 2010, we did focus on galectin research in different cancer types. Our findings showed an interaction between cancer cells and erythrocytes via galectin-4. Moreover, we found that upregulation of galectins was associated with lymph node metastasis in ovarian cancers. Hence, with More >

Fatemeh Rahbar¹, Avid Farhang Fagheh², Ayda Khosravi², Siavash Shariatzadeh^2,3,*, Reza Akhavan-Sigari⁴

Molecular & Cellular Biomechanics, Vol.18, No.4, pp. 187-199, 2021, DOI:10.32604/mcb.2021.017750 - 27 October 2021

Abstract The protein ERp57 is a stress-responsive protein, mainly exists in the endoplasmic reticulum (ER), and a small amount in the cell membrane, cytoplasm, nucleus and mitochondria, which is involved in the signal transduction from the cell surface, the regulation process that occurs in the nucleus, and the formation of polymer protein complexes involved in DNA repair. Various degrees of ERp57 dysregulation has been observed in many types of non-communicable diseases especially in cancers. Previous studies showed that the expression of ERp57 could play a key role in occurrence and development of cancers such as breast… More >