Alena A. Semenova1,*, Anastasia D. Igoshkina1, Alena A. Cherepanova1, Natalia V. Mikina1, Anastasia E. Stepanova1, Оlga E. Krasnoshchekova1, Vyacheslav A. Sharapov1, Rimma G. Savchenko2, Lyudmila V. Parfenova2, Mikhail V. Dubinin1
BIOCELL, Vol.49, No.3, pp. 437-450, 2025, DOI:10.32604/biocell.2025.061798
- 31 March 2025
Abstract Objectives: Skeletal muscle ischemia/reperfusion injury (IRI) occurs as a result of a marked reduction in arterial perfusion to a limb and can lead to tissue death and threaten limb viability. This work assessed the effects of 20-hydroxyecdysone (20E) on hindlimb skeletal tissue following tourniquet-induced ischemia/reperfusion injury. Methods: Animals were divided into 4 groups—control group (Control), Control + 20E (C + 20E), mice with IRI (IRI), and mice with IRI + 20E (IRI + 20E). IRI was modeled by applying a tourniquet to the hind limb for 2 h with reperfusion for 1 h. 5 mg/kg… More >