ZHUO YANG#, WEN QIN#, DI CHEN, JUNSHENG HUO, JINGBO WANG, LIYUAN WANG, QIN ZHUO, JIYONG YIN*
BIOCELL, Vol.47, No.1, pp. 125-131, 2023, DOI:10.32604/biocell.2023.022937
Abstract Emodin is an effective component of rhubarb with positive pharmacological effects on human health. However, it is
also toxic to different cells or tissues to varying degrees. The effects of emodin on glomerular endothelial cells (GECs) remain to
be tested, and the documented works were always performed in vitro and hardly reflect the real physiological situation. To
study the effects of emodin on GECs in a biomimetic environment, we utilized a microfluidic chip to assess the
physiological reaction of human renal glomerular endothelial cells to various concentrations of emodin in this work. The
results showed that emodin caused cytotoxicity, impaired… More >
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