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  • Open Access

    ARTICLE

    Identification of EML4 as a key hub gene for endometriosis and its molecular mechanism and potential drug prediction based on the GEO database

    XIANBAO FANG1,#, MINGYAN TANG1,#, ZIYANG YU1,#, JIAQI DING1, CHONG CUI2, HONG ZHANG1,*

    BIOCELL, Vol.47, No.9, pp. 2059-2068, 2023, DOI:10.32604/biocell.2023.030565 - 28 September 2023

    Abstract Objective: Key genes were screened to analyze molecular mechanisms and their drug targets of endometriosis by applying a bioinformatics approach. Methods: Gene expression profiles of endometriosis and healthy controls were obtained from the Gene Expression Omnibus database. Significant differentially expressed genes were screened using the limma package. Correlation pathways were screened by Spearman correlation analysis on the echinoderm microtubule-associated protein-like 4 (EML4) and enrichment in endometriosis pathways and estimated by the GSVA package. Immune characteristics were assessed by the “ESTIMATE” R package. Potential regulatory pathways were determined by enrichment analysis. The SWISS-MODE website was used in… More > Graphic Abstract

    Identification of EML4 as a key hub gene for endometriosis and its molecular mechanism and potential drug prediction based on the GEO database

  • Open Access

    ARTICLE

    An Investigation of Molecular Targeting of MMP-9 for Endometriosis Using Algal Bioactive Molecules

    Farnaz Nabiya1, Anchana Devi Chenniappan1,*, Rajamiriyam Marichamy1, MubarakAli Davoodbasha2,3, Jung-Wan Kim3,*

    Phyton-International Journal of Experimental Botany, Vol.91, No.3, pp. 569-582, 2022, DOI:10.32604/phyton.2022.017390 - 26 October 2021

    Abstract Endometriosis is a chronic inflammatory disease that occurs due to the presence of endometrial tissue outside the uterine cavity. It affects from 5% to 10% of women of reproductive age. High levels of matrix metalloproteinase (especially MMP-9) have been observed in women suffering from endometriosis. Thus, the aim of this study was to investigate the naturally anti-inflammatory compounds available from an algal source that can target the MMP-9 by various in silico approaches. The target 1L6J (Crystal structure of human matrix metalloproteinase MMP-9) structure was retrieved from the PDB database. Five compounds such as Eckol, Sargafuran,… More >

  • Open Access

    ARTICLE

    Non-bladder centric interstitial cystitis/bladder pain syndrome phenotype is significantly associated with co-occurring endometriosis

    Tyler L. Overholt1, Robert J. Evans1, Bruce A. Lessey3, Catherine A. Matthews1, Katherine N. Hines1, Gopal Badlani1, Stephen J. Walker1,2

    Canadian Journal of Urology, Vol.27, No.3, pp. 10257-10262, 2020

    Abstract Introduction: Interstitial cystitis/bladder pain syndrome (IC/BPS) and endometriosis are coexistent diagnoses in 48%-65% of women with chronic pelvic pain (CPP), suggesting that dual screening may be warranted. To further investigate the clinical relationship and risk factors between these two conditions, we performed a retrospective review of our large IC/BPS patient data registry.
    Materials and methods: We evaluated IC/BPS patients who were prospectively enrolled into our registry who completed validated questionnaires and underwent therapeutic hydrodistension, during which anesthetic bladder capacity (BC) and Hunner’s lesion (HL) status were recorded. Demographic/medical history were reviewed. IC/BPS patients with co-occurring endometriosis diagnosis… More >

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