HAORAN SU1, KEXIN LI1, XIAO LIU1,*, JING DU1, LI WANG4, XIAOYAN DENG3,*, YUBO FAN1,2,*
BIOCELL, Vol.45, No.4, pp. 797-811, 2021, DOI:10.32604/biocell.2021.014900
Abstract Endothelial cells arranged on the vessel lumen are constantly stimulated by blood flow, blood pressure and pressureinduced cyclic stretch. These stimuli are sensed through mechanical sensory structures and converted into a series of
functional responses through mechanotransduction pathways. The process will eventually affect vascular health. Therefore,
there has been an urgent need to establish in vitro endothelial biomechanics and mechanobiology of models, which
reproduce three-dimensional structure vascular system. In recent years, the rapid development in microfluidic technology
makes it possible to replicate the key structural and functionally biomechanical characteristics of vessels. Here, we
summarized the progress of microfluidic chips used… More >
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