Xingxiang Liu*†, Lin Cui†, Dong Hua*‡
Oncology Research, Vol.27, No.1, pp. 99-106, 2019, DOI:10.3727/096504018X15195193936573
Abstract We aimed to investigate the significant role of long noncoding RNA X inactive specific transcript (XIST)
in regulating tumor metastasis in colorectal cancer (CRC), as well as its possible mechanism. Expression of
lncRNA XIST in CRC tissues and CRC cells was detected. CRC cells were transfected with pc-XIST, blank
control si-XIST, or si-control, and then the effects of lncRNA XIST on CRC cell migration and invasion were
investigated, along with the interaction between lncRNA XIST and miR-137. lncRNA XIST was upregulated
in CRC tissues. Compared with HT29 cells that had low metastatic potential, XIST was markedly more highly
expressed in… More >
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