D. Grazziotin-Soares, J.-P. Lotz
Oncologie, Vol.21, No.1, pp. 69-72, 2019, DOI:10.3166/onco-2019-0030
Abstract Several studies have shown an association between Epstein-Barr virus (EBV) infection and some human
cancers such as a subgroup of gastric carcinomas. The oncogenic potential of EBV has been widely explored but the
exact processes conducting carcinogenesis are not yet fully
understood. EBV-encoded viral proteins are known to deregulate the DNA damage response (DDR) signaling pathways. DDR inactivation leads to genomic instability and
promote cellular transformation to generate malignant cells.
In a recently published article in Nature Medicine, a molecular characterization of tumor tissue and circulating tumor
DNA (cDNA) from non-selected patients with metastatic
gastric cancer treated with pembrolizumab was… More >