Guoyun Li, Wei Zhang, Li Gong, Xiaoping Huang
Oncology Research, Vol.27, No.4, pp. 449-458, 2019, DOI:10.3727/096504017X15016337254623
Abstract MicroRNAs, a class of endogenous noncoding RNAs, regulate gene expression at the posttranscriptional level
and thus take part in multiple biological processes. An increasing number of miRNAs have been found to be
dysregulated in hepatocellular carcinoma (HCC) and are involved in liver tumorigenesis. In this study, miR-
125a-5p was found to be obviously downregulated much more in hepatitis B virus (HBV)-related HCC. To
investigate the effects of miR-125a-5p, miR-125a-5p was overexpressed in HepG2.2.15 and HepG3X cells.
The findings have indicated that overexpression of miR-125a-5p dramatically inhibited cell proliferation and
induced cell apoptosis. Furthermore, overexpression of miR-125a-5p could significantly decrease the… More >
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