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    ARTICLE

    Es-ATG7 is required for spermatogenesis of Eriocheir sinensis and modulates p53-dependent apoptosis in germ cells

    SHUANG-LI HAO, FEI-DA NI, BANG-HONG WEI, ZHEN-FANG LI, TONG YANG, WAN-XI YANG*

    BIOCELL, Vol.45, No.4, pp. 971-984, 2021, DOI:10.32604/biocell.2021.015178

    Abstract Spermatogenesis is a complicated and highly regulated male gamete differentiation process that begins with the proliferation and differentiation of spermatogonia to the release of the mature spermatozoa. The autophagy-related gene atg7 has been reported as closely related to spermatogenesis and communication of Sertoli cell-germ cells in mice, including acrosome biogenesis, sperm flagellum development, and ectoplasmic specialization assembly. However, the function of es-ATG7 and its molecular regulatory mechanism during spermatogenesis in Crustacea remain largely unknown. Here, we cloned and identified es-atg7 from the testes of the Chinese mitten crabs Eriocheir sinensis and found that the expression of es-atg7 was relatively high… More >

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