Dhanjoo N. Ghista1,2, Liang Zhong2, Leok P.Chua2, Eddie Y-K Ng2, Soo T.Lim3, Ru S. Tan3, TerranceS-J Chua3
Molecular & Cellular Biomechanics, Vol.2, No.4, pp. 217-234, 2005, DOI:10.3970/mcb.2005.002.217
Abstract Background: In this paper, the left ventricle (LV) is modeled as a cylinder with myocardial fibers located helically within its wall. A fiber is modeled into myocardial structural units (MSUs); the core entity of each MSU is the sarcomeric contractile element. The relationship between the sarcomere unit's contractile force and shortening velocity is expressed in terms of the LV model's wall stress and deformation, and hence in terms of the monitored LV pressure and volume. Then, the LV systolic performance is investigated in terms of a mechatronic (excitation-contraction) model of the sarcomere unit located within the LV cylindrical model wall.… More >
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