PENG LIU1,2, ANFANG ZOU3, QI CHEN4, BIAO CHENG1,*, QIN LI1,*
BIOCELL, Vol.45, No.1, pp. 27-39, 2021, DOI:10.32604/biocell.2021.012601
Abstract The diabetic ulcer is one of the serious complications of diabetes. In this study, we aimed to establish an exosomal
microRNA (miRNA)-targeted messenger RNA (mRNA) regulatory network for screening new biomarkers for diabetic ulcer
treatment. For this purpose, exosomes were extracted from bone marrow stem cells (BMSCs) collected from diabetic ulcer
patients and healthy adults. The miRNAs in exosomes was detected by high-throughput sequencing analysis. The Gene
Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the
differential miRNAs were performed. The miRNA-mRNA regulatory network between candidate miRNAs and their
target genes were constructed by… More >
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