FEI XIE1,2, BAOHONG ZHANG1,2, WENFENG XU1, XIAOLING LIAO1,*, QIUHONG HUANG1, BO LIU2,*
BIOCELL, Vol.41, No.2-3, pp. 45-54, 2017, DOI:10.32604/biocell.2017.41.045
Abstract Focal adhesion kinase (FAK) plays a vital role in mediating the adaptability of tumor cells under
mechanical stimuli. Previous studies revealed that FAK can locate to different cell compartments, and its
regulation is highly dependent on its subcellular localization. However, the local FAK activities and its
regulation mechanism in different cell compartments of tumor cells in response to fluid shear stress are
still unclear. In this study, 5 dyn/cm2
and 20 dyn/cm2
of shear stress was applied to HeLa cells for 30 min.
The activities of FAK targeting different subcellular compartments (lipids rafts, non-rafts, focal adhesions
and cytoplasm) were investigated… More >
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