ZIQIAN WANG1,2,#, YAQI LI1,2,#, DONGYANG WANG1,2, YINGQIANG SHEN1,3,4,5,*
BIOCELL, Vol.46, No.7, pp. 1599-1611, 2022, DOI:10.32604/biocell.2022.018530
Abstract Iron-dependent ferroptosis is a form of cell death dependent on iron levels. Cells that undergo ferroptosis have
glutathione (GSH) deficiency, reduced Glutathione peroxidase-4 (GPX4) activity and intracellular lipid peroxidation,
Mitochondria, lysosomes and many signal pathways are involved in the regulation of ferroptosis. More importantly,
many tumor cells resistant to other cell death methods exhibit sensitivity to ferroptosis. Moreover, over recent years, a
number of ferroptosis-induced drugs have been recommended for the treatment of malignant tumors. Therefore, the
study of ferroptosis is of great significance for future cancer treatments. In this review, we discussed the metabolic
process of ferroptosis, the role… More >
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