JIANBO LU1,2,#,*, XIAOHAN SUN3,#, XU MA1,2,*
BIOCELL, Vol.46, No.1, pp. 185-193, 2022, DOI:10.32604/biocell.2021.015301
Abstract The concentration of cell-free fetal DNA fragments should be detected before noninvasive prenatal testing
(NIPT). The fetal DNA molecules have significant clinical potential in determining the overall performance of NIPT
and clinical interpretation. It is important to measure fetal DNA fraction before NIPT. However, there is still little
research on how to calculate the concentration of female fetuses. Two estimation approaches were proposed to
calculate fetal DNA fraction, including the fragments size-based approach, aneuploid-based approach, which are all
approaches based on chromosome segments. Based on high-throughput sequencing data, two approaches to calculate
the DNA fraction of male fetuses were tested… More >
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