TING LI1,#, XINHUI SUN2,#, NANNAN LI1, HONGMIN GUO2,*
BIOCELL, Vol.45, No.4, pp. 985-994, 2021, DOI:10.32604/biocell.2021.012371
Abstract Fibroblast growth factors (FGFs) play pivotal roles in cell migration and proliferation. However, the identity of
the FGF that plays a dominant role in kidney cell proliferation remains unclear. Therefore, in this study, we investigated
the dominant FGF among all FGFs. To this end, RNA-sequencing, qRT-PCR, western blotting, and ChIP assays were
performed. FGF9 showed the highest expression among all FGFs, and its overexpression significantly promoted
proliferation in the mouse kidney cell line C57BL/6 and increased JNK and AKT phosphorylation levels. Further,
RNA-seq analysis identified 365 upregulated and 276 downregulated genes in FGF9-overexpressed cells. These
differentially expressed genes were classified… More >
Login
Register
