Tarek Alsaied1, Jouke P. Bokma2, Mark E. Engel3, Joey M. Kuijpers2, Samuel P. Hanke1, Liesl Zuhlke4, Bin Zhang5, Gruschen R. Veldtman6
Congenital Heart Disease, Vol.12, No.4, pp. 393-398, 2017, DOI:10.1111/chd.12468
Abstract Background: Reported long-term outcome measures vary greatly between studies in Fontan
patients making comprehensive appraisal of mortality hazard challenging. We sought to create a
clinical risk score to assist monitoring of Fontan patients in the outpatient setting.
Methods: A systematic review was conducted to evaluate risk factors for long-term (beyond the
first postoperative year) mortality in Fontan patients. Studies were eligible for inclusion if ≥90
patients were included or ≥20 long-term mortalities we reported. Risk factors for long-term mortality were determined. The pooled hazard ratios were used to create components of a clinical
score for long-term mortality using meta-analysis techniques.
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