Thomas G. Wilson1,2, Yves d’Udekem1,2,3, David S. Winlaw4,5, Rachael L. Cordina5,6, Julian Ayer4,5, Thomas L. Gentles7, Robert G. Weintraub1,2,8, Leeanne E. Grigg9, Michael Cheung1,8, Timothy M. Cain10, Padma Rao10, Charlotte Verrall4, Karin Du Plessis1, Kathryn Rice7, Ajay J. Iyengar1,3
Congenital Heart Disease, Vol.14, No.3, pp. 454-463, 2019, DOI:10.1111/chd.12746
Abstract Background: Patients with a Fontan circulation are at risk of renal dysfunction. We
analyzed cross‐sectional data in pediatric and adult Fontan patients in order to assess
the accuracy of commonly used serum creatinine‐based methods in estimating glo‐
merular filtration rate (GFR).
Methods: A total of 124 Fontan patients (58 children, 66 adults) were enrolled across
three study centers. Measurement of GFR (mGFR) using in vivo 99mTc‐DTPA clear‐
ance was performed. Various serum creatinine‐based equations were used to calcu‐
late estimated GFR (eGFR).
Results: Mean mGFR was 108 ± 28 mL/min/1.73 m2
in children and 92 ± 20 mL/
min/1.73 m2… More >
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