Changyu Liu*, Yongde Liao*, Sheng Fan*, Xiangning Fu*, Jing Xiong†, Sheng Zhou†,
Man Zou‡, Jianmiao Wang§
Oncology Research, Vol.27, No.3, pp. 283-292, 2019, DOI:10.3727/096504017X15035795904677
Abstract G-protein-coupled estrogen receptor (GPER) was found to promote non-small cell lung cancer (NSCLC) by
estrogen, indicating the potential necessity of inhibiting GPER by a selective antagonist. This study was performed to elucidate the function of GPER-selective inhibitor G15 in NSCLC development. Cytoplasmic GPER
(cGPER) and nuclear GPER (nGPER) were detected by immunohistochemical analysis in NSCLC samples.
The relation of GPER and estrogen receptor (ER ) expression and correlation between GPER, ER , and
clinical factors were analyzed. The effects of activating GPER and function of G15 were analyzed in the proliferation of A549 and H1793 cell lines and development of… More >
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