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  • Open Access

    ARTICLE

    A Fair and Trusted Trading Scheme for Medical Data Based on Smart Contracts

    Xiaohui Yang, Kun Zhang*

    CMC-Computers, Materials & Continua, Vol.78, No.2, pp. 1843-1859, 2024, DOI:10.32604/cmc.2023.047660

    Abstract Data is regarded as a valuable asset, and sharing data is a prerequisite for fully exploiting the value of data. However, the current medical data sharing scheme lacks a fair incentive mechanism, and the authenticity of data cannot be guaranteed, resulting in low enthusiasm of participants. A fair and trusted medical data trading scheme based on smart contracts is proposed, which aims to encourage participants to be honest and improve their enthusiasm for participation. The scheme uses zero-knowledge range proof for trusted verification, verifies the authenticity of the patient’s data and the specific attributes of the data before the transaction,… More >

  • Open Access

    ARTICLE

    A New Micropropagation Technology of Tilia amurensis: In Vitro Micropropagation of Mature Zygotic Embryos and the Establishment of a Plant Regeneration System

    Shijie Lin1, Zimo Wang1, Hongbo Zhu2, Conghui Wang3, Hongfeng Wang2, Dawei Zhang1, Tianbing Gou1, Guangdao Bao1, Ye Luo1, Huaijiang He1, Zhonghui Zhang1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.2, pp. 277-289, 2024, DOI:10.32604/phyton.2024.046989

    Abstract Tilia amurensis is an economically valuable broadleaf tree species in Northeast China. The production of high-quality T. amurensis varieties at commercial scales has been greatly limited by the low germination rates. There is thus a pressing need to develop an organogenesis protocol for in vitro propagation of T. amurensis to alleviate a shortage of high-quality T. amurensis seedlings. Here, we established a rapid in vitro propagation system for T. amurensis from mature zygotic embryos and analyzed the effects of plant growth regulators and culture media in different stages. We found that Woody plant medium (WPM) was the optimal primary culture… More >

  • Open Access

    ARTICLE

    Prediction on Failure Pressure of Pipeline Containing Corrosion Defects Based on ISSA-BPNN Model

    Qi Zhuang1,*, Dong Liu2, Zhuo Chen3

    Energy Engineering, Vol.121, No.3, pp. 821-834, 2024, DOI:10.32604/ee.2023.044054

    Abstract Oil and gas pipelines are affected by many factors, such as pipe wall thinning and pipeline rupture. Accurate prediction of failure pressure of oil and gas pipelines can provide technical support for pipeline safety management. Aiming at the shortcomings of the BP Neural Network (BPNN) model, such as low learning efficiency, sensitivity to initial weights, and easy falling into a local optimal state, an Improved Sparrow Search Algorithm (ISSA) is adopted to optimize the initial weights and thresholds of BPNN, and an ISSA-BPNN failure pressure prediction model for corroded pipelines is established. Taking 61 sets of pipelines blasting test data… More >

  • Open Access

    ARTICLE

    Investigating Periodic Dependencies to Improve Short-Term Load Forecasting

    Jialin Yu1,*, Xiaodi Zhang2, Qi Zhong1, Jian Feng1

    Energy Engineering, Vol.121, No.3, pp. 789-806, 2024, DOI:10.32604/ee.2023.043299

    Abstract With a further increase in energy flexibility for customers, short-term load forecasting is essential to provide benchmarks for economic dispatch and real-time alerts in power grids. The electrical load series exhibit periodic patterns and share high associations with metrological data. However, current studies have merely focused on point-wise models and failed to sufficiently investigate the periodic patterns of load series, which hinders the further improvement of short-term load forecasting accuracy. Therefore, this paper improved Autoformer to extract the periodic patterns of load series and learn a representative feature from deep decomposition and reconstruction. In addition, a novel multi-factor attention mechanism… More >

  • Open Access

    ARTICLE

    Immune checkpoint receptors and their ligands on CD8 T cells and myeloma cells in extramedullary multiple myeloma

    XIAN ZHANG1, ZHUANG ZHOU2, JUNZHE WANG1, MENGMENG HAN1, HAN LIU1, MEIRONG ZANG1, JIANNING LIU1, JIAPEI LU1, JINQIAO ZHANG1, GUOCHUAN ZHANG2,*, LIXIA SUN1,#,*

    BIOCELL, Vol.48, No.2, pp. 303-311, 2024, DOI:10.32604/biocell.2023.046640

    Abstract Background: Prognosis of multiple myeloma (MM) patients with extramedullary disease (EMD) remains poor. T cell dysfunction and an immunosuppressive environment have been reported in the bone marrow (BM) of MM patients. However, the immunosuppressive microenvironment and immune checkpoint receptors (ICRs) on CD8 T cells in the EMD tissue of newly diagnosed MM (NDMM) patients have not been thoroughly studied. Methods: We investigated the expression levels of T cell immunoglobulin mucin-domain-containing-3 (TIM-3) and T-cell immunoglobulin and ITIM domain (TIGIT) on CD8 T cells and the expression of their ligands (Galectin-9 and CD155) on myeloma cells in EMD tissue of NDMM patients.… More > Graphic Abstract

    Immune checkpoint receptors and their ligands on CD8 T cells and myeloma cells in extramedullary multiple myeloma

  • Open Access

    ARTICLE

    Overexpression of RUNX1 mitigates dexamethasone-induced impairment of osteogenic differentiation and oxidative stress injury in bone marrow mesenchymal stem cells by promoting alpha-2 macroglobulin transcription

    QINGJIAN HE1, HUIXIN ZHU2,3, SHANHONG FANG4,5,*

    BIOCELL, Vol.48, No.2, pp. 205-216, 2024, DOI:10.32604/biocell.2023.045109

    Abstract Introduction: Dexamethasone (Dex) caused impaired osteoblast differentiation and oxidative stress (OS) in bone marrow mesenchymal stem cells (BMSCs). This work sought to elucidate the precise molecular pathway through which Dex influences osteogenic differentiation (OD) and OS in BMSCs. Methods: The expression of Runt-related transcription factor 1 (RUNX1) and alpha-2 macroglobulin (A2M) was assessed in Dex-treated BMSCs using qRT-PCR and Western Blot. Following the functional rescue experiments, cell proliferation was determined by MTT assay, reactive oxygen species (ROS) expression by DCFH-DA fluorescent probe, lactate dehydrogenase (LDH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (Gpx) expression by kits, OD by alkaline… More >

  • Open Access

    ARTICLE

    E3 ubiquitin ligase CBL-B suppresses vascular endothelial cell pyroptosis and injury in intracranial aneurysm by facilitating NLRP3 degradation

    WEI ZHENG1, CHENG LIU2,*

    BIOCELL, Vol.48, No.2, pp. 293-301, 2024, DOI:10.32604/biocell.2023.044211

    Abstract Objective: Intracranial aneurysm (IA) represents a devastating disease with high rates of disability and mortality, which is initiated by dysfunction of endothelial cells (ECs). Evidence suggests the dysregulation of the E3 ubiquitin ligase family during EC injury. In this work, the role of an E3 ubiquitin ligase, casitas B lymphoma-B (CBL-B), was explored in human brain microvascular EC (HBMEC) function through the NLRP3 pathway. Methods: In vitro IA model was induced by treating HBMECs with oxidized low-density lipoprotein (ox-LDL). The levels of CBL-B and pyroptosis-related proteins NLRP3, ASC, cleaved caspase-1, and GSDME-N were determined by real-time-quantitative polymerase chain reaction and… More >

  • Open Access

    ARTICLE

    Valtrate exerts anticancer effects on gastric cancer AGS cells by regulating reactive oxygen species-mediated signaling pathways

    JINGLONG CAO1,#, SHUMEI LI2,#, TONG ZHANG1,#, JIAN LIU1, WENSHUANG HOU1, ANQI WANG1, CHANG WANG3,4,*, CHENGHAO JIN1,3,5,*

    BIOCELL, Vol.48, No.2, pp. 313-325, 2024, DOI:10.32604/biocell.2023.043474

    Abstract Background: Valtrate (Val) was extracted from the Valeriana jatamansi Jones plant, had good antitumor activity. However, its precise molecular mechanism in cancer cells was still unclear. This study investigated the effect of Val on gastric cancer (GC) cells and its potential molecular mechanism. Methods: Cell viability was examined by CCK-8 assay. Cell cycle, apoptosis, and Reactive oxygen species (ROS) level were analyzed by flow cytometry. The migration effect of Val on AGS cells was analyzed by transwell and wound-healing assay. The expression levels of proteins were analyzed by western blot. Results: The cell viability assay results demonstrated that Val significantly… More > Graphic Abstract

    Valtrate exerts anticancer effects on gastric cancer AGS cells by regulating reactive oxygen species-mediated signaling pathways

  • Open Access

    ARTICLE

    Coverless Image Steganography System Based on Maze Game Generation

    Al Hussien Seddik Saad1, Mohammed S. Reda2, Gamal M. Behery2, Ahmed A. El-harby2, Mohammed Baz3, Mohamed Abouhawwash4,5,*, Ahmed Ismail Ebada6

    Intelligent Automation & Soft Computing, Vol.38, No.2, pp. 125-138, 2023, DOI:10.32604/iasc.2023.032084

    Abstract The trend of digital information transformation has become a topic of interest. Many data are threatening; thus, protecting such data from attackers is considered an essential process. Recently, a new methodology for data concealing has been suggested by researchers called coverless steganography. Coverless steganography can be accomplished either by building an image database to match its image subblocks with the secret message to obtain the stego image or by generating an image. This paper proposes a coverless image steganography system based on pure image generation using secret message bits with a capacity higher than the other traditional systems. The system… More >

  • Open Access

    ARTICLE

    Gastric cancer secreted miR-214-3p inhibits the anti-angiogenesis effect of apatinib by suppressing ferroptosis in vascular endothelial cells

    WEIXUE WANG#, TONGTONG WANG#, YAN ZHANG, TING DENG, HAIYANG ZHANG*, YI BA*

    Oncology Research, Vol.32, No.3, pp. 489-502, 2024, DOI:10.32604/or.2023.046676

    Abstract Different from necrosis, apoptosis, autophagy and other forms of cell death, ferroptosis is a mechanism that catalyzes lipid peroxidation of polyunsaturated fatty acids under the action of iron divalent or lipoxygenase, leading to cell death. Apatinib is currently used in the third-line standard treatment of advanced gastric cancer, targeting the anti-angiogenesis pathway. However, Apatinib-mediated ferroptosis in vascular endothelial cells has not been reported yet. Tumor-secreted exosomes can be taken up into target cells to regulate tumor development, but the mechanism related to vascular endothelial cell ferroptosis has not yet been discovered. Here, we show that exosomes secreted by gastric cancer… More >

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