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    Safflower (Carthamus Tinctorius L.) a Potential Source of Drugs against Cryptococcal Infections, Malaria and Leishmaniasis

    Aknur Turgumbayeva1,2, Gulbaram Ustenova1, Ubaidilla Datkhayev1, Khairolla Rahimov3, Silvijus Abramavicius4,5, Agile Tunaityte4,*, Kairat Zhakipbekov1,6, Kaldanay Kozhanova1, Saken Tulemissov7, OzikhanUstenova8, Gulmira Datkayeva9, Edgaras Stankevicius1,10

    Phyton-International Journal of Experimental Botany, Vol.89, No.1, pp. 137-146, 2020, DOI:10.32604/phyton.2020.07665

    Abstract In this research we present that Carthamus Tinctorius L. (gen. Asteraceae, otherwise known as Safflower) (Fig. 1) may contain agents active in Cryptococcal infections, malaria and Leishmaniasis, as treatment options are becoming scarce due to drug resistance development. Phytochemistry and pharmacological activities (antimicrobial, antimalarial, antileishmanial) of C. tinctorius L. were analyzed. The composition of volatile oil of safflower dried flowers was analyzed by gas chromatography-mass spectrophotometry with flame ionization detector (GC-FID) and in vitro sensitivity assays were performed to assess biological activity. 8 known and 3 unknown compounds were detected in the extract (Fig. 1). Then the Safflower ointment was… More >

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