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    The characterization of transmembrane protein 59-like (TMEM59L) reveals its role in the regulating the level of the GDI protein family


    BIOCELL, Vol.46, No.12, pp. 2615-2624, 2022, DOI:10.32604/biocell.2022.021247

    Abstract The characterization and functions of transmembrane protein 59-like (TMEM59L), a type I transmembrane protein, are not clearly understood until now. Some TMEM59L and fluorescent fusion proteins constructs were transfected in cell lines and liposomes, and their localization was observed. The effects of protein constructs were studied by fluorescence microscopy and western blotting. This study reports a novel function of human TMEM59L (hTMEM59L) related to the expression and location of some proteins. In addition, we report two novel splice variants of human TMEM59L (hTMEM59L). The localization of mutants of this protein, lacking a middle region, and… More >

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