Anastasia Vylegzhanina^1,2, Irina Shalaginova^2,*, Dana Korolevich¹, Dmitry Katserov¹, Alexandra Semenova¹, Maria Sidorova¹, Sergey Eresko³, Marat Airapetov³, Marina Pavlova², Anna Levina², Natalia Dyuzhikova²

BIOCELL, Vol.49, No.10, pp. 2007-2031, 2025, DOI:10.32604/biocell.2025.071198 - 22 October 2025

Abstract Objectives: Chronic stress can trigger neuroinflammation and gut microbiota alterations, contributing to post-stress disorders. Individual differences in stress responses, shaped by genetic and physiological factors, require better characterization. We aimed to investigate the long-term effects of chronic stress in rats selectively bred for high and low nervous system excitability. Methods: Adult male rats from two strains selectively bred for high (HT) and low (LT) excitability thresholds of the nervous system underwent a 15-day chronic emotional-pain stress protocol. Behavioral assessments (elevated plus maze), cytokine levels (TNF, IL-1β, IL-6, IL-10) in the hippocampus and amygdala measured by… More >

Guo-Zhi Xu^1,2, Han-Yang Guan¹, Yan-Guan Guo¹, Yi-Ran Zhang¹, Jing-Hua Pan¹, Simin Luo³, Hui Ding¹, Yunlong Pan^1,*, Qi Yao^4,*

Oncology Research, Vol.33, No.8, pp. 1947-1967, 2025, DOI:10.32604/or.2025.060440 - 18 July 2025

Abstract Background: Tumor angiogenesis is related to solid tumor occurrence. Ubiquitin-specific peptidase 13 (USP13) is a deubiquitinating enzyme with a pivotal effect on tumor proliferation, metastasis, and tumorigenesis. Nonetheless, its effect on colorectal cancer (CRC) angiogenesis remains poorly understood. Methods: Human umbilical vein endothelial cells (HUVECs) and CRC cells were cultivated, followed by USP13 knockdown/overexpression using shRNA lentiviral vectors or plasmids. Conditioned media (CM) from treated CRC cells were collected to assess HUVEC migration, invasion, and tube formation. Phosphatase and tensin homolog (PTEN) overexpression and recombinant vascular endothelial growth factor A (VEGFA) rescue experiments were performed.… More >

Stanislav Aladev^1,*, Dmitry Sokolov¹, Maxim Politko¹, Galina Kazanskaya¹, Svetlana Aidagulova^1,2, Elvira Grigorieva^1,3

BIOCELL, Vol.49, No.6, pp. 1057-1069, 2025, DOI:10.32604/biocell.2025.064100 - 24 June 2025

Abstract Background: Glucocorticoids are used as anti-inflammatory drugs for the treatment of various diseases, however, their side effects on normal brain tissue remain underinvestigated. Objectives: The study aimed to investigate dexamethasone (DXM) effects on cell composition and myelin content in the mouse brain tissue. Methods: C57Bl/6 male mice (n = 60) received single and ten multiple intraperitoneal DXM injections (2.5 mg/kg), and the studied parameters were analysed at 1, 3, 7, 10 days after a single DXM injection and 15, 30, 60, and 90 days after the multiple injections. Oligodendrocytes, microglia, and astrocytes were assayed by immunohistochemistry… More >

MAN REN^1,2,3,#, YUAN YANG^1,2,#, DAN LI⁴, NANNAN ZHAO⁵, YUPING WANG^2,6,*, YONGNING ZHOU^2,6,*

BIOCELL, Vol.47, No.5, pp. 977-989, 2023, DOI:10.32604/biocell.2023.028402 - 10 April 2023

Abstract Background: 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) is a natural polyphenolic compound derived from multiple medicinal plants with favorable anticancer activity. Methods: In this study, the mechanisms of PGG against gastric cancer were explored through network pharmacology and molecular docking. First, the targets of PGG were searched in the Herbal Ingredients’ Targets (HIT), Similarity Ensemble Approach (SEA), and Super-PRED databases. The potential targets related to gastric cancer were predicted from the Human Gene Database (GeneCards) and DisGeNET databases. The intersecting targets of PGG and gastric cancer were obtained by Venn diagram and then subjected to protein-protein interaction analysis to screen… More >

Chenjing Su¹, Xiaoyu Li^1,*, Mengru Li², Qinsheng Zhu², Hao Fu², Shan Yang³

Journal of Quantum Computing, Vol.3, No.2, pp. 79-87, 2021, DOI:10.32604/jqc.2021.016651 - 22 June 2021

Abstract As an ideal material, bulk metallic glass (MG) has a wide range of applications because of its unique properties such as structural, functional and biomedical materials. However, it is difficult to predict the glass-forming ability (GFA) even given the criteria in theory and this problem greatly limits the application of bulk MG in industrial field. In this work, the proposed model uses the random forest classification method which is one of machine learning methods to solve the GFA prediction for binary metallic alloys. Compared with the previous SVM algorithm models of all features combinations, this More >

Katarina Mirjačić Martinović¹, Milica Milićević¹, Annette K Larsen², Radan Džodić^3,4, Vladimir Jurišić⁵, Gordana Konjević^1,4, Ana Vuletić¹

European Cytokine Network, Vol.30, No.4, pp. 160-167, 2019, DOI:10.1684/ecn.2019.0440

Abstract Objective: Stage II melanoma patients have high risk for regional and distant metastases and may benefit from novel therapeutic strategies. To clarify the role of NK cells in Stage II melanoma, we characterized the cytotoxic activity of NK cells and the expression of various activating and inhibitory receptors in high-risk cutaneous melanoma patients (Stages IIB and IIC) compared to low-risk patients (Stage IA). Materials and Methods: Native and cytokinetreated peripheral blood mononuclear cells were used for functional and phenotypical analyses. Results: Compared to Stage IA-B patients, Stage IIB-C patients showed significantly decreased NK cell activity,… More >

LETTY MARCANO, INGRID CARRUYO, YUSMARY FERNÁNDEZ, XIOMARA MONTIEL, ZAIDA TORREALBA.

BIOCELL, Vol.30, No.2, pp. 259-267, 2006, DOI:10.32604/biocell.2006.30.259

Abstract The vanadium is a metal that presents great interest from the toxicological point of view, because of the numerous alterations that can take place in different biological systems. This work evaluated the capacity of vanadium accumulation and its correlation with genotoxic effects in root cells of Allium cepa L. The bulbs were cultivated in renovated filtered water each 24 h, at a temperature of 25 ± 0.5°C, in darkness and constant aeration. Treatments were carried out under the same experimental conditions, using water solutions of vanadium of 25, 50, 75 and 100μg/g for 0, 12, 24,… More >