Bo Ling, Zuliang Huang, Suoyi Huang, Li Qian, Genliang Li, Qianli Tang
Oncology Research, Vol.28, No.6, pp. 561-578, 2020, DOI:10.3727/096504020X15907428281601
Abstract There is growing evidence on the clinical significance of tumor microenvironment (TME) cells in predicting prognosis and therapeutic effects. However, cell interactions in tumor microenvironments have not been
thoroughly studied or systematically analyzed so far. In this study, 22 immune cell components in the lung
adenocarcinoma (LUAD) TME were analyzed using gene expression profile from The Cancer Genome Atlas
(TCGA) and Gene Expression Omnibus (GEO). The TME-based molecular subtypes of LUAD were defined
to evaluate further the relationship between molecular subtypes, prognosis, and clinical characteristics. A TME
risk score model was constructed by using the differentially expressed genes (DEGs) of… More >
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