Chunmei Pang^1,2, Bo Sui^2,3, Kangyu Wang^2,*

Phyton-International Journal of Experimental Botany, Vol.95, No.8, 2026, DOI:10.32604/phyton.2026.085307 - 28 August 2026

Abstract As an important medicinal plant in China, Panax ginseng is rich in secondary metabolites and is widely used in immune regulation, antitumor, anti-aging applications. The exocyst complex is a crucial protein complex that regulates vesicle trafficking in plants and plays key roles in cellular secretion, polar growth, and stress responses. Methyl jasmonate (MeJA) is a widely occurring derivative of jasmonic acid (JA) in plants and belongs to the category of endogenous signaling molecules in plants, which significantly regulates plant defense and secondary metabolism. MeJA is a key signaling molecule that significantly regulates plant defense and secondary… More >

Kangjia Fan¹, Biao He^2,*, Shahab Hosseini³, Seyed Yaser Mousavi Siamakani^4,*

CMES-Computer Modeling in Engineering & Sciences, Vol.148, No.2, 2026, DOI:10.32604/cmes.2026.084187 - 28 August 2026

Abstract Mining activities are associated with environmental side effects, which can be successfully predicted and strategies proposed for mitigating their adverse impacts. The cleaner production policies of green blasting focus on ecological issues related to mining operations and reduction plans. As a prediction part of this policy, this research proposed a mathematical model named Gene Expression Programming (GEP) to accurately predict the factors that generated pollutions, i.e., total suspended particles (TSP), particles dust with an analogous aerodynamic diameter of less than 10 μm (PM₁₀), and dust emission distance due to mine blasting (DEMB), simultaneously. As the reduction… More > Graphic Abstract

Abtin Tondar^1,2,*, David Hervás Marín³, Laura Calvet Liñán⁴, Asim Kumar Bepari⁵

Oncology Research, Vol.34, No.9, 2026, DOI:10.32604/or.2026.082424 - 13 August 2026

Abstract Background: Chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are B-cell malignancies with distinct cellular origins and microenvironmental dependencies. We aimed to identify concordant transcriptomic signatures and candidate transcriptional regulatory features between CLL CD19-positive B cells and MM-associated bone marrow-derived mesenchymal stromal cells (MSCs). Methods: Public Gene Expression Omnibus bulk RNA sequencing datasets were analyzed separately within each context using DESeq2. Differentially expressed genes (DEGs) were defined using adjusted p-value < 0.05 and absolute log₂ fold change > 1. Cross-disease analyses assessed overlap, directionality, log₂ fold-change concordance, expressed-gene background-adjusted enrichment, coexpression structure, and transcription factor annotation. Results: We… More >

Yasmine Labiad¹, Céline Baier¹, Michèle Genin², Caroline Besson^3,4, Sophie Prevot⁵, Hubert Lepidi⁶, Régis Costello^1,7,*

Oncology Research, Vol.34, No.8, 2026, DOI:10.32604/or.2026.076241 - 16 July 2026

Abstract Objectives: Transcriptomic profiling has enabled the classification of Diffuse Large B-Cell Lymphoma (DLBCL) into distinct subtypes, such as Germinal Center B-cell-like (GCB) and Activated B-cell-like (ABC), primarily in HIV-negative patients. However, HIV-associated DLBCL may follow different molecular mechanisms due to immune dysregulation. This study aimed to characterize the transcriptomic landscape of HIV-related DLBCL to identify distinct subtypes and deregulated pathways with potential theranostic implications. Methods: Twelve formalin-fixed, paraffin-embedded DLBCL samples from HIV-positive patients were analyzed using Agilent’s microarray. Quantile normalization and unsupervised hierarchical clustering were performed to classify tumors based on gene expression profiles. Results: Two distinct More > Graphic Abstract

Maram Fahaad Almufareh^1,*, Samabia Tehsin^2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.147, No.3, 2026, DOI:10.32604/cmes.2026.081129 - 30 June 2026

Abstract This article presents a Hierarchical Pathway-Masked Attention Autoencoder (H-PAAE), a biologically inspired representation-learning framework that enables explainable AI-guided cancer diagnosis. The model directly integrates the curated MSigDB Hallmark pathways, introducing pathway-constrained information flow and mechanistic interpretability through multi-level attention mechanisms. Based on TCGA RNA-seq data from 33 tumor types, H-PAAE compresses approximately 20,000 genes into a 128-dimensional latent space while preserving biologically meaningful structure. When used with XGBoost classification, H-PAAE delivers 92.37% test accuracy and 99.38% macro-AUROC with robust cross-validation results (92.5 ± 0.6%). SHAP analysis identifies a small number of key latent features, corresponding More >

Shaowei Zhang^1,2,#, Bingbing Li^3,#, Xiaogai Zhao^2,#, Guoqiang Fan^1,*

Phyton-International Journal of Experimental Botany, Vol.95, No.5, 2026, DOI:10.32604/phyton.2026.081526 - 27 May 2026

Abstract Growth regulatory factor (GRF) genes play a crucial role in plant growth and development, reproduction, metabolism, and stress resistance. In this study, we conducted a genome-wide integrated analysis of transcriptome and miRNA expression profiles in Paulownia fortunei challenged by phytoplasma infection, with a specific focus on elucidating the functional landscape of the PfGRF transcription factor (TF) family. A comprehensive investigation was conducted on the PfGRF TF family. A total of 16 PfGRF genes were identified in this study, among which 13 were located on the chromosomes of P. fortunei. They were divided into six groups based on amino acid… More >

Evangelos Manousakis¹, Cristina Moreta-Moraleda¹, Clàudia Martinez Miralles¹, Anna Tomàs Pujolà¹, Houda Baccara², Laia Liñán Franquet¹, Montserrat Montañés Albó¹, Roberto Ferrari², Roni H. G. Wright^1,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.074965 - 22 April 2026

Abstract Objective: Breast cancer remains one of the most prevalent malignancies among women worldwide, and despite advances in therapy and treatment options, tumour relapse and metastasis remain major clinical challenges, largely driven by the breast cancer stem cells (BCSCs) niche that resists conventional treatments and regenerates tumours. In breast cancer, where approximately 30% of patients who initially respond to treatment ultimately relapse and die of metastatic disease, targeting BCSCs is critical for improving patient outcomes. Cyclin-dependent kinase inhibitor 1A/p21 (CDKN1A/p21) is a multifunctional protein that is known primarily for its role in regulating the cell cycle… More > Graphic Abstract

Fen Liu^1,2, Cheng Qu^1,3,*, Hongliang Yuan³, Xinpeng Xiang³, Yingbo Chen³, Yuxuan Cai³, Yue Wang^4,*

Phyton-International Journal of Experimental Botany, Vol.95, No.3, 2026, DOI:10.32604/phyton.2026.077734 - 31 March 2026

Abstract To explore the physiological mechanism of rice seeds’ tolerance to cold damage stress, the hybrid rice variety H-You 518 and the conventional rice variety Zhongjiazao 17 were used as experimental materials. A low-temperature cold damage treatment (4°C) and a normal germination treatment (25°C) were used to measure seed vitality, antioxidant enzyme activity, soluble sugar content, soluble protein content, α-amylase activity, endopeptidase, and related gene expression levels. The results showed that low temperature inhibited seed vitality and germination ability, and after restoring normal growth conditions, the activities of POD and CAT, as well as the content… More >

Ina Shehaj^1,2,*, Slavomir Krajnak¹, Katrin Almstedt¹, Yaman Degirmenci¹, Roxana Schwab¹, Kathrin Stewen¹, Walburgis Brenner¹, Annette Hasenburg¹, Marcus Schmidt^1,#, Anne-Sophie Heimes^1,#

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.072222 - 24 February 2026

Abstract This article has no abstract. More >

Enrique Oropeza-Maetínez¹, Eva G. Palacios-Serrato¹, Marina Macías-Silva², Angeles C. Tecalco-Cruz^1,*

European Cytokine Network, Vol.36, No.3, pp. 38-51, 2025, DOI:10.1684/ecn.2025.0503 - 28 February 2026

Abstract Background: Glioblastoma is a lethal primary brain tumor that is therapeutically challenging due to its rapid progression. Interferon-gamma (IFN-γ) signaling is altered in glioblastoma. Moreover, proteolytic enzymes, known as proteases, have been linked to the invasive growth of cancerous cells. In this study, we aimed to identify a glioblastoma-associated protease group and to determine its potential connection with IFN-γ signaling. Methods: Using cancer expression databases, we analyzed the differential expression of 35 proteases in glioblastoma and healthy brain tissue, and the relevance of their deregulation to patient survival. We also explored correlations between IFN-γ signaling… More >