Yasmine Labiad¹, Céline Baier¹, Michèle Genin², Caroline Besson^3,4, Sophie Prevot⁵, Hubert Lepidi⁶, Régis Costello^1,7,*

Oncology Research, Vol.34, No.8, 2026, DOI:10.32604/or.2026.076241 - 16 July 2026

Abstract Objectives: Transcriptomic profiling has enabled the classification of Diffuse Large B-Cell Lymphoma (DLBCL) into distinct subtypes, such as Germinal Center B-cell-like (GCB) and Activated B-cell-like (ABC), primarily in HIV-negative patients. However, HIV-associated DLBCL may follow different molecular mechanisms due to immune dysregulation. This study aimed to characterize the transcriptomic landscape of HIV-related DLBCL to identify distinct subtypes and deregulated pathways with potential theranostic implications. Methods: Twelve formalin-fixed, paraffin-embedded DLBCL samples from HIV-positive patients were analyzed using Agilent’s microarray. Quantile normalization and unsupervised hierarchical clustering were performed to classify tumors based on gene expression profiles. Results: Two distinct More > Graphic Abstract

Maram Fahaad Almufareh^1,*, Samabia Tehsin^2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.147, No.3, 2026, DOI:10.32604/cmes.2026.081129 - 30 June 2026

Abstract This article presents a Hierarchical Pathway-Masked Attention Autoencoder (H-PAAE), a biologically inspired representation-learning framework that enables explainable AI-guided cancer diagnosis. The model directly integrates the curated MSigDB Hallmark pathways, introducing pathway-constrained information flow and mechanistic interpretability through multi-level attention mechanisms. Based on TCGA RNA-seq data from 33 tumor types, H-PAAE compresses approximately 20,000 genes into a 128-dimensional latent space while preserving biologically meaningful structure. When used with XGBoost classification, H-PAAE delivers 92.37% test accuracy and 99.38% macro-AUROC with robust cross-validation results (92.5 ± 0.6%). SHAP analysis identifies a small number of key latent features, corresponding More >

Shaowei Zhang^1,2,#, Bingbing Li^3,#, Xiaogai Zhao^2,#, Guoqiang Fan^1,*

Phyton-International Journal of Experimental Botany, Vol.95, No.5, 2026, DOI:10.32604/phyton.2026.081526 - 27 May 2026

Abstract Growth regulatory factor (GRF) genes play a crucial role in plant growth and development, reproduction, metabolism, and stress resistance. In this study, we conducted a genome-wide integrated analysis of transcriptome and miRNA expression profiles in Paulownia fortunei challenged by phytoplasma infection, with a specific focus on elucidating the functional landscape of the PfGRF transcription factor (TF) family. A comprehensive investigation was conducted on the PfGRF TF family. A total of 16 PfGRF genes were identified in this study, among which 13 were located on the chromosomes of P. fortunei. They were divided into six groups based on amino acid… More >

Evangelos Manousakis¹, Cristina Moreta-Moraleda¹, Clàudia Martinez Miralles¹, Anna Tomàs Pujolà¹, Houda Baccara², Laia Liñán Franquet¹, Montserrat Montañés Albó¹, Roberto Ferrari², Roni H. G. Wright^1,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.074965 - 22 April 2026

Abstract Objective: Breast cancer remains one of the most prevalent malignancies among women worldwide, and despite advances in therapy and treatment options, tumour relapse and metastasis remain major clinical challenges, largely driven by the breast cancer stem cells (BCSCs) niche that resists conventional treatments and regenerates tumours. In breast cancer, where approximately 30% of patients who initially respond to treatment ultimately relapse and die of metastatic disease, targeting BCSCs is critical for improving patient outcomes. Cyclin-dependent kinase inhibitor 1A/p21 (CDKN1A/p21) is a multifunctional protein that is known primarily for its role in regulating the cell cycle… More > Graphic Abstract

Fen Liu^1,2, Cheng Qu^1,3,*, Hongliang Yuan³, Xinpeng Xiang³, Yingbo Chen³, Yuxuan Cai³, Yue Wang^4,*

Phyton-International Journal of Experimental Botany, Vol.95, No.3, 2026, DOI:10.32604/phyton.2026.077734 - 31 March 2026

Abstract To explore the physiological mechanism of rice seeds’ tolerance to cold damage stress, the hybrid rice variety H-You 518 and the conventional rice variety Zhongjiazao 17 were used as experimental materials. A low-temperature cold damage treatment (4°C) and a normal germination treatment (25°C) were used to measure seed vitality, antioxidant enzyme activity, soluble sugar content, soluble protein content, α-amylase activity, endopeptidase, and related gene expression levels. The results showed that low temperature inhibited seed vitality and germination ability, and after restoring normal growth conditions, the activities of POD and CAT, as well as the content… More >

Ina Shehaj^1,2,*, Slavomir Krajnak¹, Katrin Almstedt¹, Yaman Degirmenci¹, Roxana Schwab¹, Kathrin Stewen¹, Walburgis Brenner¹, Annette Hasenburg¹, Marcus Schmidt^1,#, Anne-Sophie Heimes^1,#

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.072222 - 24 February 2026

Abstract This article has no abstract. More >

Enrique Oropeza-Maetínez¹, Eva G. Palacios-Serrato¹, Marina Macías-Silva², Angeles C. Tecalco-Cruz^1,*

European Cytokine Network, Vol.36, No.3, pp. 38-51, 2025, DOI:10.1684/ecn.2025.0503 - 28 February 2026

Abstract Background: Glioblastoma is a lethal primary brain tumor that is therapeutically challenging due to its rapid progression. Interferon-gamma (IFN-γ) signaling is altered in glioblastoma. Moreover, proteolytic enzymes, known as proteases, have been linked to the invasive growth of cancerous cells. In this study, we aimed to identify a glioblastoma-associated protease group and to determine its potential connection with IFN-γ signaling. Methods: Using cancer expression databases, we analyzed the differential expression of 35 proteases in glioblastoma and healthy brain tissue, and the relevance of their deregulation to patient survival. We also explored correlations between IFN-γ signaling… More >

Qunlu Liu^1,#, Fiza Liaquat^1,2,#, Qiqi Tang¹, Jun Yang^3,4, Shuai Qiu⁵, Amber Malik², Kang Ye^3,4, Kai Gao⁵, Jun Qin^3,4,*

Phyton-International Journal of Experimental Botany, Vol.94, No.11, pp. 3539-3562, 2025, DOI:10.32604/phyton.2025.071989 - 01 December 2025

Abstract Hydrangea macrophylla is a popular ornamental shrub with a lot of economic and aesthetic value. It is known for its different flower shapes (lacecap and mophead) and the way its flowers change color depending on the pH of the soil. Even though it is important for gardening, we still don’t know much about the molecular processes that lead to flower growth. The purpose of this study was to find and study SNP-related genes and transcription factors that are connected to the growth of H. macrophylla flowers. Genome-wide SNP analysis identified 11 SNPs associated with MYB transcription factors… More >

Rawabi S. Altuwayjiri, Ibtesam S. Almami^*

Oncology Research, Vol.33, No.12, pp. 3923-3943, 2025, DOI:10.32604/or.2025.070104 - 27 November 2025

Abstract Objective: Testicular germ cell tumors (TGCTs) represent the most common malignancy among young men aged 20–40 years. Transglutaminase 7 (TG7), encoded by TGM7, is a poorly characterized enzyme whose function in TGCT remains unknown. This study aimed to assess TG7 expression in clinical specimens and investigate its functional role in a testicular germ cell tumor cell line (NT2/D1). Methods: TG7 protein expression was evaluated in clinical testicular tissue samples via immunohistochemistry (IHC) and immunofluorescence (IF). Functional analysis was conducted in the NT2/D1 human testicular cancer cell line using Dicer-substrate small interfering RNAs (DsiRNAs) targeting TG7. Gene… More >

Abdil Hakan Eren^*

Phyton-International Journal of Experimental Botany, Vol.94, No.10, pp. 3085-3107, 2025, DOI:10.32604/phyton.2025.069506 - 29 October 2025

Abstract The FAR1-related sequence (FAR1) gene family consists of transcription factors that originated from transposases and is crucial for light signaling and stress adaptation in plants. Despite the recognized importance of FAR1 genes in model organisms, their genomic architecture, structural variability, and expression patterns in Phaseolus vulgaris have yet to be investigated. This study offers the inaugural comprehensive genome-wide identification and characterization of the FAR1 gene family in P. vulgaris. A total of 27 PvulFAR1 genes were identified, and their chromosomal distribution, gene structures, conserved domains, and phylogenetic relationships were analyzed systematically. The promoter regions of these genes were discovered… More >