WEI LI1,2, YUEYANG DUAN1, XIAOTONG YAN1, XIANGXIANG LIU1, MEILING FAN3,*, ZI WANG1,2,*
BIOCELL, Vol.46, No.6, pp. 1417-1423, 2022, DOI:10.32604/biocell.2022.017609
Abstract Ginsenoside Rb3 (G-Rb3) is one of the primary active compounds isolated from Panax ginseng Meyer, which belongs to protopanaxadiol ginsenosides (PPD). Based on the structure-activity relationship (SAR) of ginsenosides, the pentose structure of G-Rb3 limited itself to possess more pharmacological activity to a certain extent. However, pharmacokinetics show that G-Rb3 is processed through deglycosylation in the intestinal tract and converted into more active rare saponins, such as Compound K, F2, etc. A series of studies focused on neuroprotection and the cardiovascular system demonstrating its therapeutic potentials, which was achieved by diminishing oxidative stress and apoptosis. Therefore, more systematic and in-depth… More >
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