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    Decreased invasion ability of hypotaurine synthesis deficient glioma cells was partially due to hypomethylation of Wnt5a promoter

    Hong TIAN1, 2, Peiyu CONG3, Ruiqun QI4, Xinghua GAO5, Xin LIU6, Hongsheng LIU7, Fengping SHAN1,*

    BIOCELL, Vol.41, No.1, pp. 27-32, 2017, DOI:10.32604/biocell.2017.41.027

    Abstract Glioma is one of the lethal central nervous system tumors. The infiltrative and invasive growth nature makes it difficult to identify the boundary between glioma and the normal tissues, resulting in inevitable recurrence after surgery operation. Gliomas do not metastasize, so to prevent the residual tumor from proliferating or invading is a key challenge. Previous report indicated that hypotaurine could facilitate glioma invasion and suppress demethylases’ activities. Using a hypotaurine synthesis deficient U251 cell line, we proved that the cells invasion ability was impaired. Gene expression profile analysis exhibited that knocking down one of the key enzymes of hypotaurine synthesis,… More >

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