SUFANG ZHANG1,2,#, XIANG LV1,#, LI LI3,#, YINGBIN LUO1, HUINAN XIANG1, LIXIN WANG2,*, YAN LI1,*
BIOCELL, Vol.45, No.1, pp. 167-175, 2021, DOI:10.32604/biocell.2021.013636
Abstract Chemotherapy is widely used for non-small cell lung cancer (NSCLC) patients at a late stage; however, NSCLC
patients often acquire resistance to chemotherapeutic drugs, thus limiting the therapy efficacy. Melittin, a major
component of bee venom, possesses anti-tumor activity in various cancer cells. Here, we examined the effects of
melittin on A549/DDP cisplatin-resistant lung adenocarcinoma cells and xenografts formed from this cell line and
investigated the possible target of melittin. Treatment with melittin resulted in the induction of cell apoptosis,
glycolysis inhibition, and reduction of phosphorylated AKT (p-AKT) in A549/DDP cells. We also identified that
tripartite motif-containing 8 (TRIM8) was… More >
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