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    Glypican-3 versus alpha-fetoprotein as a biomarker for hepatocellular carcinoma: a diagnostic meta-analysis

    Weiyu FU1, Hongyu LU2, Li LI3, Kefeng WU3, Yanping LI3, Yi LIU3,*, Jianli HU4,*

    BIOCELL, Vol.39, No.2-3, pp. 25-32, 2015, DOI:10.32604/biocell.2015.39.025

    Abstract Objective: To assess the diagnostic accuracy of serum GPC3 versus alpha-fetoprotein (AFP) for HCC by using the method of system review.
    Methods: PubMed and EMBASE were searched from its inception to 20, April 2014 for studies that compared diagnostic accuracy of serum GPC3 with AFP for HCC. Sensitivity, specificity and other measures were pooled using random-effects models. Summary receiver operating characteristic curve analysis was used to summarize the overall test performance.
    Results: Fourteen studies were included in this meta-analysis. Summary estimates for serum GPC3 and AFP in diagnosing HCC were as follows: sensitivity, 69% (95% confidence interval (CI), 56-80%) vs.… More >

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