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  • Open Access

    RETRACTION

    Retraction: Knockdown of Urothelial Carcinoma-Associated 1 Suppressed Cell Growth and Migration Through Regulating miR-301a and CXCR4 in Osteosarcoma MHCC97 Cells

    Oncology Research Editorial Office

    Oncology Research, Vol.32, No.8, pp. 1381-1381, 2024, DOI:10.32604/or.2024.055035

    Abstract This article has no abstract. More >

  • Open Access

    RETRACTION

    Retraction: Propofol Inhibits Lung Cancer A549 Cell Growth and Epithelial-Mesenchymal Transition Process by Upregulation of MicroRNA-1284

    Oncology Research Editorial Office

    Oncology Research, Vol.32, No.8, pp. 1377-1377, 2024, DOI:10.32604/or.2024.055033

    Abstract This article has no abstract. More >

  • Open Access

    REVIEW

    Hypoxia-inducible factor 1alpha and vascular endothelial growth factor in Glioblastoma Multiforme: a systematic review going beyond pathologic implications

    DIMITRA P. VAGELI1,2,*, PANAGIOTIS G. DOUKAS3, KERASIA GOUPOU2, ANTONIOS D. BENOS2, KYRIAKI ASTARA2,4, KONSTANTINA ZACHAROULI2, SOTIRIS SOTIRIOU5, MARIA IOANNOU2

    Oncology Research, Vol.32, No.8, pp. 1239-1256, 2024, DOI:10.32604/or.2024.052130

    Abstract Glioblastoma multiforme (GBM) is an aggressive primary brain tumor characterized by extensive heterogeneity and vascular proliferation. Hypoxic conditions in the tissue microenvironment are considered a pivotal player leading tumor progression. Specifically, hypoxia is known to activate inducible factors, such as hypoxia-inducible factor 1alpha (HIF-1α), which in turn can stimulate tumor neo-angiogenesis through activation of various downward mediators, such as the vascular endothelial growth factor (VEGF). Here, we aimed to explore the role of HIF-1α/VEGF immunophenotypes alone and in combination with other prognostic markers or clinical and image analysis data, as potential biomarkers of GBM prognosis… More >

  • Open Access

    ARTICLE

    Analysis of the role of dihydromyricetin derived from vine tea (Ampelopsis grossedentata) on multiple myeloma by activating STAT1/RIG-I axis

    WEI JIANG1, MEI ZHOU2,*

    Oncology Research, Vol.32, No.8, pp. 1359-1368, 2024, DOI:10.32604/or.2024.043423

    Abstract Multiple myeloma (MM) is a plasma cell malignancy and remains incurable as it lacks effective curative approaches; thus, novel therapeutic strategies are desperately needed. The study aimed to explore the therapeutic role of dihydromyricetin (DHM) in MM and explore its mechanisms. Human MM and normal plasma samples, human MM cell lines, and normal plasma cells were used for in vitro experiments. Cell counting kit-8 (CCK-8), flow cytometry, and trans-well assays were performed for the assessment of cell viability, apoptosis, migration, and invasion, respectively. Quantitative real-time polymerase chain reaction (qRT-PCR) was employed to assess the mRNA expression… More > Graphic Abstract

    Analysis of the role of dihydromyricetin derived from vine tea (<i>Ampelopsis grossedentata</i>) on multiple myeloma by activating STAT1/RIG-I axis

  • Open Access

    ARTICLE

    Relationship between Seed Priming Mediated Seedling Vigor and Yield Performance of Spring Wheat

    Md. Parvez Anwar*, Masuma Akhter, Sharmin Aktar, Sinthia Afsana Kheya, A. K. M. Mominul Islam*, Sabina Yeasmin, Ahmed Khairul Hasan, Md. Harun Or Rashid

    Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1159-1177, 2024, DOI:10.32604/phyton.2024.049073

    Abstract Seed priming is a pre-germinated technique that can enhance seed germination percentage, faster and synchronized germination, better seedling growth, and yield under stress conditions. To ascertain the most effective seed priming method that would ensure the potential yield of wheat in Bangladesh, two experiments were carried out from December 2021 to March 2022 at the Department of Agronomy, Bangladesh Agricultural University. Two wheat varieties namely BARI Gom-28 and BWMRI Gom-1 were subjected to a range of priming chemicals in both lab and pot tests. These compounds included the following: control (no priming), hydropriming (distilled water),… More >

  • Open Access

    ARTICLE

    Effect of Light Emitting Diodes (LEDs) on Growth, Mineral Composition, and Nutritional Value of Wheat & Lentil Sprouts

    Abdul Momin1, Amana Khatoon1,*, Wajahat Khan1, Dilsat Bozdoğan Konuşkan2, Muhammad Mudasar Aslam3, Muhammad Jamil4, Shafiq Ur Rehman5, Baber Ali6, Alevcan Kaplan7, Sana Wahab8, Muhammad Nauman Khan9,*, Sezai Ercisli10,11, Mohammad Khalid Al-Sadoon12

    Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1117-1128, 2024, DOI:10.32604/phyton.2024.048994

    Abstract Sprouts are ready-to-eat and are recognized worldwide as functional components of the human diet. Recent advances in innovative agricultural techniques could enable an increase in the production of healthy food. The use of light-emitting diode (LED) in indoor agricultural production could alter the biological feedback loop, increasing the functional benefits of plant foods such as wheat and lentil sprouts and promoting the bioavailability of nutrients. The effects of white (W), red (R), and blue (B) light were investigated on the growth parameters and nutritional value of wheat and lentil sprouts. In the laboratory, seeds were… More >

  • Open Access

    ARTICLE

    MicroRNA-155 Downregulation Promotes Cell Cycle Arrest and Apoptosis in Diffuse Large B-Cell Lymphoma

    Fu-qiang Zhu*1, Li Zeng†1, Na Tang*, Ya-ping Tang, Bo-ping Zhou*, Fang-fang Li*, Wei-gang Wu*, Xiao-bing Zeng*, Shu-song Peng*

    Oncology Research, Vol.24, No.6, pp. 415-427, 2016, DOI:10.3727/096504016X14685034103473

    Abstract Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin’s lymphoma in the adult population, and treatment of DLBCL is still unfavorable. Therefore, there is an urgent requirement to investigate the molecular mechanisms underlying DLBCL tumorigenesis. To study the potential function of microRNA-155 (miR-155) involved in the regulation of lymphoma, we monitored lymphoma cell behavior including proliferation, cell cycle, and apoptosis using CCK-8 and flow cytometry analysis. Real-time PCR was used to detect the expression levels of miR-155 in 118 lymphoma patients’ tissues, and Western blot was also used to analyze the expression level of… More >

  • Open Access

    ARTICLE

    Suppressive Role of MicroRNA-148a in Cell Proliferation and Invasion in Ovarian Cancer Through Targeting Transforming Growth Factor-β-Induced 2

    Min Zhao*, Zhiying Su, Shiyang Zhang, Liangjin Zhuang§, Yudi Xie*, Xiaodong Li*

    Oncology Research, Vol.24, No.5, pp. 353-360, 2016, DOI:10.3727/096504016X14685034103275

    Abstract Ovarian cancer (OC) is one of the most common gynecological malignancies. MicroRNAs (miRs) play a crucial role in the development and progression of OC, but the underlying mechanism remains largely unclear. Our study investigated the regulatory role of miR-148a in OC cell proliferation and invasion. We found that miR- 148a was significantly downregulated in OC tissues compared to their matched adjacent nontumor tissues. In addition, its expression was also reduced in OC cell lines (SKOV3, ES-2, OVCAR, and A2780) compared to normal ovarian epithelial cells. Overexpression of miR-148a caused a significant decrease in OC cell… More >

  • Open Access

    ARTICLE

    Knockdown of REV7 Inhibits Breast Cancer Cell Migration and Invasion

    Liu Feng*†, Wang Wei*, Zhang Heng, Han Yantao, Wang Chunbo

    Oncology Research, Vol.24, No.5, pp. 315-325, 2016, DOI:10.3727/096504016X14666990347590

    Abstract REV7 (also known as MAD2L2) is a multifunctional protein involved in DNA damage tolerance, cell cycle regulation, gene expression, and carcinogenesis. Although its expression is reportedly associated with poor prognosis in several kinds of human cancers, the significance of REV7 expression in breast malignancies is unclear. In this study, REV7 was found to be increased in breast cancer. We found that knockdown of REV7 inhibited the migration, invasion, and epithelial–mesenchymal transition (EMT) of breast cancer cells. Meanwhile, overexpression of REV7 promoted the migration, invasion, and EMT of breast cancer cells. As shown by Western blot, More >

  • Open Access

    ARTICLE

    Anexelekto (AXL) Increases Resistance to EGFR-TKI and Activation of AKT and ERK1/2 in Non-Small Cell Lung Cancer Cells

    Yaqiong Tian*1, Zengli Zhang†1, Liyun Miao*, Zhimin Yang, Jie Yang*, Yinhua Wang§, Danwen Qian, Hourong Cai*, Yongsheng Wang*

    Oncology Research, Vol.24, No.5, pp. 295-303, 2016, DOI:10.3727/096504016X14648701447814

    Abstract Recently, epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have revolutionized nonsmall cell lung cancer (NSCLC) treatment. However, resistance remains a major obstacle. Anexelekto (AXL) is a member of receptor tyrosine kinases (RTKs) and shares the same downstream signaling pathways with EGFR, such as PI3K/AKT and MAPK/ERK. AXL overexpression in resistant tumors has been implicated in many previous studies in vitro and in vivo. In this study, we further examined whether expression of AXL and its downstream targets increased in gefitinib-resistant PC9 cells (PC9GR). In addition, we hypothesize that knocking down AXL in PC9GR and… More >

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