ASPASIA MANTA1, SPYRIDON KAZANAS2, STEFANOS KARAMAROUDIS3, HELEN GOGAS2, DIMITRIOS C. ZIOGAS2,*
Oncology Research, Vol.30, No.5, pp. 211-219, 2022, DOI:10.32604/or.2022.026913
Abstract Epigenetic mechanisms, such as DNA methylation and histone modifications (e.g., acetylation and
deacetylation), are strongly implicated in the carcinogenesis of various malignancies. During transcription, the
expression and functionality of coding gene products are altered following the histone acetylation and deacetylation.
These processes are regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), respectively.
HDAC inhibitors (HDACis) have been developed as promising therapeutic agents, to limit exposure to traditional
and toxic chemotherapies and offer more alternatives for some specific malignant diseases with limited options.
Mechanistically, these agents affect many intracellular pathways, including cell cycle arrest, apoptosis and
differentiation, and their mechanism… More >
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