Xing Chen, Wu Zhou, Qinghua Hu, Lingjin Huang
Congenital Heart Disease, Vol.14, No.3, pp. 396-402, 2019, DOI:10.1111/chd.12733
Abstract Objective: This study explores the role of the Notch3‐HES5 signal pathway in mono‐
crotaline‐induced pulmonary hypertension (PH) using rat models.
Method: Sprague Dawley rats (n = 45) were randomly grouped into normal group,
control group, and model group. Rats in the model group were used to establish the
PH rat model. Four weeks after model establishment, right catheterization was used
to measure the mean pulmonary arterial pressure (mPAP) and right ventricular sys‐
tolic pressure (RVSP) to analyze hemodynamic changes. The severity of PH was as‐
sessed by the right ventricular hypertrophy index (RVHI) and percentage of media
thickness (MT%). The… More >
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