Yaghoub Dabiri1,3, Kevin L. Sack1,2, Semion Shaul1, Gabriel Acevedo-Bolton1, Jenny S. Choy3, Ghassan S. Kassab3, Julius M. Guccione1,*
Molecular & Cellular Biomechanics, Vol.16, No.3, pp. 185-197, 2019, DOI:10.32604/mcb.2019.07364
Abstract We hypothesized that minimally invasive injections of a softening agent at strategic locations in stiff myocardium could de-stiffen the left ventricle (LV) globally. Physics-based finite element models of the LV were created from LV echocardiography images and pressures recorded during experiments in four swine. Results confirmed animal models of LV softening by systemic agents. Regional de-stiffening of myocardium led to global de-stiffening of LV. The mathematical set up was used to design LV global de-stiffening by regional softening of myocardium. At an end diastolic pressure of 23 mmHg, when 8 ml of the free wall was covered by intramyocardial injections,… More >
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