DONG ZHAO, QIANG JI*, SHIJIE ZHU, KAI ZHU, CHUNSHENG WANG*
BIOCELL, Vol.44, No.3, pp. 315-321, 2020, DOI:10.32604/biocell.2020.09169
Abstract Except for the standard aortic valve replacement, no effective medical treatment is available to prevent or delay
calcific aortic valve disease (CAVD) progression. Recently, macrophages and high-mobility group box 1 (HMGB1) are the
most intriguing candidates in various inflammatory disorders. However, the association between serum HMGB1, CAVD,
and macrophage polarization remains unclear. Therefore, we examined whether the level of serum HMGB1 is clinically
associated with aortic valve calcification and whether HMGB1 treatment can promote macrophage differentiation toward
M1 or M2 phenotype. This experimental study included 19 CAVD patients and 20 healthy controls whose serum HMGB1
levels were examined by ELISA… More >
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