FU-MING TSAI1, PING-HSUN LU2,3, LU-KAI WANG4, CHAN-YEN KUO1, MAO-LIANG CHEN1, CHUN-HUA WANG5,6,*
BIOCELL, Vol.47, No.8, pp. 1793-1802, 2023, DOI:10.32604/biocell.2023.030093
Abstract Background: Cisplatin is a chemotherapeutic agent commonly used clinically for the treatment of various human cancers. Patients often reduce the use of cisplatin due to its side effects, which in turn affects its treatment. This study explored the mechanism of action of safflower extract as an adjuvant traditional Chinese medicine for chemotherapy. Methods: Primary human follicle dermal papilla cells (HFDPCs) were used as target cells for cisplatin-induced damage to hair cells. Western blotting was used to investigate the molecular targets of cisplatin and safflower extract in causing HFDPCs damage. Cell survival and cell cycle were analyzed by mitochondrial staining reagent… More >
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