Kecheng Zhou*†1,
Jie Chen*†1,
Jiayu Wu*†1,
Yangxinzi Xu‡, Qiaoyun Wu*†, Jingjing Yue*†, Yu Song§,
Shengcun Li*†, Peng Zhou¶, Wenzhan Tu*†, Guanhu Yang*†, Songhe Jiang*†
Oncology Research, Vol.27, No.9, pp. 1079-1088, 2019, DOI:10.3727/096504019X15579146061957
Abstract Profilin 2 (PFN2) was found to be mainly expressed in neurons and involved in the development of the brain. In
recent years, emerging evidence indicated that PFN2 is also significantly upregulated in various cancers including head and neck cancer (HNSC) and influences cancer cell proliferation, migration, and invasion. However,
the role of PFN2 in HNSC development and progression remains unclear. The aim of our study was to investigate the role of PFN2 in the development of HNSC and its possible molecular mechanisms. Bioinformatics
showed that increased expression of PFN2 in tumors correlated highly with poor prognosis of HNSC patients.
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