Mahmoud Al-Azaba, Jing Weia, Xunli Ouyang, Abdalkhalig Elkhidera, Williams Walana, Xiaotong Sun, Yawei Tang, Bing Wang, Xia Li
European Cytokine Network, Vol.29, No.1, pp. 27-35, 2018, DOI:10.1684/ecn.2018.0405
Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joints inflammation.
One of the aggressive characteristics of RA fibroblast-like synoviocytes (FLS) is the tendency for migration in the
local environment, which plays a central role in the RA pathogenesis. Tumor Necrosis Factor (TNF)-like cytokine
1A (TL1A) is a member of TNF superfamily, which has a role in autoimmunity and influences the RA-FLS behavior
through TNF receptor 2 (TNFR2). We investigated the effect of TNF-like cytokine 1A (TL1A) on RA-FLS migration
using patients’ samples. Specifically, we examined the hedgehog signaling pathway which is a key More >
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