CHUNJIAO LIU1,2, QINHONG KONG1,2, FENG PAN1,2, SHAN JIANG1,2, LINGJIE MENG1,2, GAI HUANG1,2, LIDAN LU1,2, SANHUA LI1,2,*, YUN LIU1,2,3,*
BIOCELL, Vol.45, No.4, pp. 943-951, 2021, DOI:10.32604/biocell.2021.015836
Abstract Traditional Chinese medicine (TCM) has been increasingly applied in both preventing and treating a variety of
cancers in the last decades, attributing to its fewer side effects as compared with chemotherapy drugs. Hellebrigenin, a
component of Chanpi from the skin of Bufo bufogargarizans Cantor or Duttaphrynus melanostictus has been reported
to have an obvious anti-cancer activity on various cancers. However, the effect and mechanism of hellebrigenin on
colorectal cancers were still unknown. Herein, the present study demonstrated hellebrigenin significantly reduced
viability and triggered apoptosis via the intrinsic pathway in colorectal cancer cell lines HCT116 and HT29 in vitro
and in… More >
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