R. Canabarro^1,2, H. Sporleder², T. Gomes^3,4, G. Zanatta^3,5, L. Scribel^3,6, F. Freitas⁷, J. Neumann², P. Pranke^1,3

BIOCELL, Vol.31, No.3, pp. 397-403, 2007, DOI:10.32604/biocell.2007.31.397

Abstract The use of umbilical cord blood stem cells is an efficient alternative for the transplantation of hematopoietic progenitor cells. A number of factors can influence the volume and amount of CD34⁺ cells, which are considered as immature and capable of proliferation. Quantification of CD34⁺ cells, evaluation of CD38 and c-kit molecules on these cells, as well as correlations of such factors as maternal age, gestational age, newborn sex and weight, umbilical cord length, placental weight with increased volume and concentration of immature cells, among others, were performed in 70 blood samples from term newborns. The mean volume of umbilical cord… More >

Pan Zhang^1,2, Chen Zhang^1,2, Jiyang Han^1,2, Xiru Liu^1,2, Qishan Wang³, Hui Yang^1,2,4,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 132-132, 2019, DOI:10.32604/mcb.2019.06839

Abstract Research in stem cell biology relies on the knowledge of the cell microenvironment in vivo, known as “stem cell niche”, where stem cells are nurtured by the niche signals. Hematopoietic stem cells (HSCs) are capable of continuously generating and maintaining the body’s full immune and hematopoietic systems. In adult, a pool of hematopoietic cells, including HSCs, primarily reside in the bone marrow (BM) niches that plays critical roles on cell fate. Niche supporting cells, cytokines, extracellular matrix proteins and other biochemical cues associated with HSCs behaviors (quiescence, self-renewal, proliferation, differentiation, mobilization, homing, and apoptosis) has been revealed in quantity. Recently… More >