HUNG-WEI LIN1, PEI YU LEE1, YU-SHIUAN CHANG1, MAU-SUN CHANG1,2,*
Oncology Research, Vol.33, No.2, pp. 493-503, 2025, DOI:10.32604/or.2024.053791
- 16 January 2025
Abstract Background: Rho GTPases are essential regulators for cellular movement and intracellular membrane trafficking. Their enzymatic activities fluctuate between active GTP-bound and inactive GDP-bound states regulated by GTPase activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs). Arhgap39/Vilse/Porf-2 is a newly identified GAP. The role of Arhgap39 in migration and invasion has not been addressed thoroughly. Methods: The Arhgap39 gene was knocked out by Crispr-Cas9 gene editing in mouse Hepa1-6 and Hepa-1c1c7 cells to analyze the impact of Arhgap39 depletion on migration and invasion. Results: Loss of Arhgap39 noticeably increased the migration and invasive potential. Purified Arhgap39… More >
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