YONGDAE YOON1,#, SOONJAE HWANG1,2,#, FATEMA TUJ SAIMA3,#, MOON YOUNG KIM1,3,4, SOON KOO BAIK1,3,4,*, YOUNG WOO EOM1,3,*
BIOCELL, Vol.47, No.3, pp. 669-676, 2023, DOI:10.32604/biocell.2023.025365
Abstract Background: Activated hepatic stellate cells (HSCs) are closely involved in the initiation, perpetuation, and
resolution of liver fibrosis. Pro-inflammatory cytokine levels are positively correlated with the transition from liver
injury to fibrogenesis and contribute to HSC pathophysiology in liver fibrosis. Methods: In this study, we investigated
the effect of the pro-inflammatory cytokine interleukin (IL)-1β on the proliferation and signaling pathways involved
in fibrogenesis in LX-2 cells, an HSC cell line, using western blotting and cell proliferation assays. Results: IL-1β
increased the proliferation rate and α-smooth muscle actin (SMA) expression of LX-2 cells in a dose-dependent
manner. Within 1 h after… More >
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