Qiaodong Xu1, Songgang Gu1, Jiahong Liang, Zhihua Lin, Shaodong Zheng, Jiang Yan
Oncology Research, Vol.27, No.4, pp. 509-514, 2019, DOI:10.3727/096504018X15278771272963
Abstract Hepatocellular carcinoma (HCC) is one of the major malignant tumors that lead to death. Chronic hepatitis B
virus infection is an important risk factor for HCC initiation. HBx protein, encoded by the HBV X gene, is a
significant factor that promotes HBV-related HCC, although the exact molecular mechanism remains unclear.
This article summarizes the pathological roles and related mechanisms of HBx in HCC. HBx plays a carcinogenic role by promoting cell proliferation, metastasis, and angiogenesis and inhibiting apoptosis in HCC. A
detailed study of the biological functions of HBx will help to elucidate the mechanism of hepatocarcinogenesis
and lead to… More >
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