Maria Angeles Jimenez-Sousa1, Raquel Almansa2, Concha de la Fuente1, Agustín Caro-Paton3, Lourdes Ruiz4, Gloria Sanchez-Antolín3, Jose Manuel Gonzalez4, Rocio Aller4, Noelia Alcaide3, Pilar Largo1, Salvador Resino5, Raul Ortiz de Lejarazu6, Jesus F. Bermejo-Martin2
European Cytokine Network, Vol.21, No.2, pp. 84-91, 2010, DOI:10.1684/ecn.2010.0191
Abstract Hepatitis C virus causes significant morbidity and mortality worldwide. The infection induces upregulation
of cytokine and chemokines commonly linked to the development of cellular and pro-inflammatory
antiviral responses. The current standard in hepatitis C treatment consists of combination regimens of
pegylated interferon-alpha plus ribavirin. The impact of combined treatment in the host immune response is
still poorly understood. In the present study, we profiled 27 cytokines, chemokines and growth factors involved
in the innate and adaptive responses to the virus in the serum of 27 hepatitis C virus-infected patients, before
and after 12 weeks of… More >
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